Los Angeles, June 21st, 2028. While the streets are being torn apart by riots, the Nurse, who runs a clandestine hospital for criminals in the penthouse of the Artemis, a closed old hotel, has a rough night dealing with troublemaker clients: thieves, assassins, someone from the past and the one who owns the place and the whole city. Set in riot-torn, near-future Los Angeles, 'Hotel Artemis' follows the Nurse, who runs a secret, members-only emergency room for criminals.