When Van Helsing's mysterious invention, the Monsterfication Ray, goes haywire, Drac and his monster pals are all transformed into humans, and Johnny becomes a monster. In their new mismatched bodies, Drac and Johnny must team up and race across the globe to find a cure before it's too late, and before they drive each other crazy. After one experiment, Johnny turns into a monster and everyone else becomes human. Now it has to be seen whether they will be able to reverse this experiment.