Based upon Tyler Perry's acclaimed stage production, Madea's Family Reunion continues the adventures of Southern matriarch Madea. She has just been court ordered to be in charge of Nikki, a rebellious runaway, her nieces, Lisa and Vanessa, are suffering relationship trouble, and through it all, she has to organize her family reunion. While planning her family reunion, a pistol-packing grandma must contend with the other dramas on her plate, including the runaway who has been placed under her care, and her love-troubled nieces.