Rookie cop, Amelia Donaghy reluctantly teams with Lincoln Rhyme – formerly the department's top homicide detective but now paralyzed as a result of a spinal injury – to catch a grisly serial killer dubbed 'The Bone Collector'. The murderer's special signature is to leave tantalizing clues based on the grim remains of his crimes. A quadriplegic ex-homicide detective and his partner try to track down a serial killer who is terrorizing New York City.