Tom the cat and Jerry the mouse get kicked out of their home and relocate to a fancy New York hotel, where a scrappy employee named Kayla will lose her job if she can’t evict Jerry before a high-class wedding at the hotel. Her solution? Hiring Tom to get rid of the pesky mouse. A chaotic battle ensues between Jerry Mouse, who has taken refuge in the Royal Gate Hotel, and Tom Cat, who is hired to drive him away before the day of a big wedding arrives.